Outbreak of organophosphorus compound-induced delayed neurotoxicity in water buffaloes

Organophosphorus Compound Induced 'Intermediate Syndrome'

Side effects of organophosphorus compounds: delayed neurotoxicity.

Many organophosphorus compounds produce a chronic toxicity that has been classified as a dying-back process in which the long axons are particularly affected. Recent evidence indicates that an essential first step in the production of the lesion is the phosphorylation of a protein that is able to hydrolyse substrates such as phenyl phenylacetate. The esterase activity of the protein is inhibite...

Organophosphorus ester-induced chronic neurotoxicity.

Organophosphorus compounds are potent neurotoxic chemicals that are widely used in medicine, industry, and agriculture. The neurotoxicity of these chemicals has been documented in accidental human poisoning, epidemiological studies, and animal models. Organophosphorus compounds have 3 distinct neurotoxic actions. The primary action is the irreversible inhibition of acetylcholinesterase, resulti...

Effects of prednisolone and complex of vitamin B1, B2, B6 and B12 on organophosphorus compound-induced delayed neurotoxicity.

Protective effects of prednisolone as a synthetic adrenal cortical hormone and complex of vitamin B(1), B(2), B(6) and B (12) on organophosphorus compound-induced delayed neurotoxicity (OPIDN) caused by leptophos and tri-o-cresyl phosphate (TOCP) as organophosphates (OPs) were examined. Nine groups of hens (six for each) were used. Eight groups received intravenous injection of 30 mg/kg of lept...

[Structure-reactivity relationships and delayed neurotoxicity of organophosphorus compounds].

A correlation has been found between the reactivity in the alkaline hydrolysis reaction of a new series of organophosphates and their ability or disability to produce the clinical manifestations of delayed neurotoxicity in hen. At a dose of 1000 mg/kg only compounds exceeding a lower limit of reactivity (about 6x10-2 M-1S-1) are active.